In a new study in mice, scientists have compensated for mutations in the Brca1 gene that can lead to cancer by deleting a second gene, which then lessens the probability of cancer. Mice Brca1-associated mammary tumors have significant similarities to human BRCA1- associated (BReast CAncer 1, early onset) breast cancer in regard to tumor aggressiveness, high incidence, mutations and genetic instability. The study, led by scientists at National Cancer Institute (NCI), part of the National Institutes of Health, and their colleagues, appeared online April 1, 2010 and in print April 16, 2010, in the journal Cell.

Related posts:

1. Medicare Card, Scientists Identify Markers, Human Breast Cancer Cells, Linked to Development of an Aggressive, But Less Common Form of Breast Cancer Scientists have identified a group of surface markers on cells linked to an aggressive type of breast cancer called estrogen receptor-negative cancer. In this preliminary study, estrogen-negative breast cancer developed when three markers, CD44+, CD49fhi, and CD133hi were present simultaneously on the surface of human cells taken from breast cancer patients and transplanted into a [...]...
2. Medicare Card: Gene Linked to Alzheimer’s Disease Plays Key Role in Cell Survival Scientists have discovered that a gene linked to Alzheimer’s disease may play a beneficial role in cell survival by enabling neurons to clear away toxic proteins. A study funded by the National Institute on Aging (NIA), part of the National Institutes of Health, shows the presenilin 1 (PS1) gene is essential to the function of [...]...
3. Medicare Blog, New Study Implicates Healthcare Utilization Rates, More than Biology, in Colorectal Cancer Disparities Higher rates of colorectal cancer incidence and mortality experienced by African-Americans may be driven largely by differences in health care utilization, and less by biology, according to a new study led by researchers from the National Cancer Institute (NCI), part of the National Institutes of Health....
4. MedicareCard.com, Experimental Immune, Boosting Drug Worsens TB in Mice An experimental drug that boosts production of the immune system protein interferon worsens tuberculosis (TB) in mice, according to scientists from the National Institutes of Health. The drug acts indirectly by drawing certain immune cells, in which Mycobacterium tuberculosis (M.tb) bacteria thrive, to the lungs. The findings may have potential implications for the care of people infected with TB, the authors note. The research is reported in the May 3 issue of Journal of Clinical Investigation, now available online....
5. Researchers design a light therapy that targets and destroys cancer cells in mice Researchers have designed a light-based therapy that allows the selective destruction of tumor cells in mice without harming surrounding normal tissue. This method of cancer therapy could theoretically work against tumors in humans, such as those of the breast, lung, prostate, as well as cancer cells in the blood such as leukemias, say scientists from [...]...
6. Medicare, Researchers discover key mutation in acute myeloid leukemia Researchers have discovered mutations in a particular gene that affects the treatment prognosis for some patients with acute myeloid leukemia (AML), an aggressive blood cancer that kills 9,000 Americans annually. The scientists report their results in the Nov. 11, 2010, online issue of The New England Journal of Medicine....
7. Medicare Health Checkups – Comparing Models that Assess Breast Cancer Risk A new study found that models for assessing breast cancer risk perform only slightly better when they include common inherited genetic variants recently linked to the disease. For now, recommendations for breast cancer screening or treatments that are based on such models will remain unchanged for most women....
8. Gene Associated with Rare Adrenal Disorder Appears To Trigger Cell Death, According to NIH Study A gene implicated in Carney complex, a rare disorder of the adrenal glands, appears to function as a molecular switch to limit cell growth and division, according to a study by researchers at the National Institutes of Health and other institutions....
9. Medicare, Medicare Card, Statement by HHS, NIH Director Regarding the President’s Intent, Appoint Dr. Harold Varmus as Director of the National Institute of Cancer at the National Institutes of Health Dr. Harold Varmus brings a vast wealth of expertise to this key leadership position at the Department. Among his many professional distinctions, he is a Nobel laureate in cancer genetics; has been president of one of the premier cancer research and treatment institutions for the past decade; and previously has served the public as NIH [...]...
10. Medicare, Gene Variant that may Prevent African Sleeping Sickness also Leads to Increased Chance of Kidney Disease National Institutes of Health researchers and grantees have found that gene variants in APOL1, more common in African Americans, come with both health risk and reward, as reported in the July 15 online issue of Science....
11. Medicare, Gene Pattern, May Identify Kidney Transplant Recipients, Who Don’t Need Life-long Anti-rejection Drugs Researchers have identified a distinct pattern of gene expression in the largest reported group of kidney transplant recipients who have not rejected the transplant kidneys even though they stopped taking anti-rejection drugs. This finding may help identify other transplant recipients who could safely reduce or end use of immunosuppressive therapy. In 2008, more than 80,000 [...]...
12. Vitamin D Status is Not Associated with Risk for Less Common Cancers Despite hopes that higher blood levels of vitamin D might reduce cancer risk, a large study finds no protective effect against non-Hodgkin lymphoma or cancer of the endometrium, esophagus, stomach, kidney, ovary, or pancreas. In this study, carried out by researchers from the National Cancer Institute (NCI), part of the National Institutes of Health, and [...]...
13. Additional Genes Associated with Age-Related Macular Degeneration Identified Additional Genes Associated with Age-Related Macular Degeneration Identified...
14. Harold Varmus Sworn in as National Cancer Institute’s 14th Director Nobel Prize winner Harold E. Varmus, M.D., today took the oath of office to become the National Cancer Institute’s (NCI) 14th director. NCI is one of the 27 Institutes and Centers that comprise the National Institutes of Health (NIH)....
15. Study identifies gene that suppresses cell’s immune activation A new study of prostate tumors has shown that a gene, FOXO3, suppresses activation of cells related to immunity and thus leads to a reduced immune response against a growing cancer. One of the main problems in treating cancer by vaccine or immunotherapy is that tumors often evade the body’s immune response — and one [...]...