NIH-funded research suggests deficient DNA repair may lead to dementia.  Mutant forms of breast cancer factor 1 (BRCA1) are associated with breast and ovarian cancers but according to new findings, in the brain the normal BRCA1 gene product may also be linked to Alzheimer’s disease. The results, published in Nature Communications, suggest that low levels of BRCA1 protein in the brain may contribute to dementia. The study was funded by the National Institutes of Health.

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  1. Medicare Future? Pathways that Can Repair Brca1 Cancer Gene Mutation Clarified in Mice In a new study in mice, scientists have compensated for mutations in the Brca1 gene that can lead to cancer by deleting a second gene, which then lessens the probability of cancer. Mice Brca1-associated mammary tumors have significant similarities to human BRCA1- associated (BReast CAncer 1, early onset) breast cancer in regard to tumor aggressiveness, high incidence, mutations and genetic instability. The study, led by scientists at National Cancer Institute (NCI), part of the National Institutes of Health, and their colleagues, appeared online April 1, 2010 and in print April 16, 2010, in the journal Cell....
  2. Medicare Card, Scientists Identify Markers, Human Breast Cancer Cells, Linked to Development of an Aggressive, But Less Common Form of Breast Cancer Scientists have identified a group of surface markers on cells linked to an aggressive type of breast cancer called estrogen receptor-negative cancer. In this preliminary study, estrogen-negative breast cancer developed when three markers, CD44+, CD49fhi, and CD133hi were present simultaneously on the surface of human cells taken from breast cancer patients and transplanted into a […]...
  3. Medicare Card: Gene Linked to Alzheimer’s Disease Plays Key Role in Cell Survival Scientists have discovered that a gene linked to Alzheimer’s disease may play a beneficial role in cell survival by enabling neurons to clear away toxic proteins. A study funded by the National Institute on Aging (NIA), part of the National Institutes of Health, shows the presenilin 1 (PS1) gene is essential to the function of […]...
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  7. Medicare Card. Breast Cancer Awareness Early Detection Saves Lives Breast cancer affects 1 in 8 women. Although it’s one of the deadliest cancers in the United States, breast cancer is often treatable when detected early.  Mammograms, which are low-dose x-rays of the breast, continue to be vital in the early detection of breast cancer....
  8. Medicare Card, Study reveals how genetic changes lead to familial Alzheimer’s disease Medicare Card, Study reveals how genetic changes lead to familial Alzheimer’s disease...
  9. Medicare Card, Risk gene for Alzheimer’s disease associated with lower brain amyloid Medicare Card, Risk gene for Alzheimer’s disease associated with lower brain amyloid...
  10. Medicare Card, Study breaks blood-brain barriers to understanding Alzheimer’s NIH-funded study suggests brain blood vessel cells may be therapeutic targets for Alzheimer’s disease.   study in mice shows how a breakdown of the brain’s blood vessels may amplify or cause problems associated with Alzheimer’s disease. The results published in Nature Communications suggest that blood vessel cells called pericytes may provide novel targets for treatments and […]...
  11. Medicare Card, NIH-funded researchers create next-generation Alzheimer’s disease model Medicare Card, NIH-funded researchers create next-generation Alzheimer's disease model...
  12. Medicare Card, Study reveals genomic similarities between breast cancer and ovarian cancers Medicare Card, Study reveals genomic similarities between breast cancer and ovarian cancers...
  13. Medicare Card, Mammograms Help With Breast Cancer Early Detection Medicare Card, Mammograms Help With Breast Cancer Early Detection...
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  15. Medicare Health Checkups – Comparing Models that Assess Breast Cancer Risk A new study found that models for assessing breast cancer risk perform only slightly better when they include common inherited genetic variants recently linked to the disease. For now, recommendations for breast cancer screening or treatments that are based on such models will remain unchanged for most women....