The long-held approach to predicting seasonal influenza vaccine effectiveness may need to be revisited, new research suggests. Currently, seasonal flu vaccines are designed to induce high levels of protective antibodies against hemagglutinin (HA), a protein found on the surface of the influenza virus that enables the virus to enter a human cell and initiate infection. New research conducted by scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, found that higher levels of antibody against a different flu surface protein — neuraminidase (NA) — were the better predictor of protection against flu infection and its unpleasant side effects. Neuraminidase, which is not currently the main target antigen in traditional flu vaccines, enables newly formed flu viruses to exit the host cell and cause further viral replication in the body.
In light of serious problems identified in the NIH Clinical Center Pharmaceutical Development Section last year, NIH launched a multifaceted effort to ensure that processes for patient safety and quality of care at the hospital are of the highest standards. Accordingly, NIH hired two companies specializing in quality assurance for manufacturing and compounding — Working Buildings and Clinical IQ — to evaluate all of its facilities producing sterile or infused products for administration to research participants. This evaluation is underway and preliminary findings have identified facilities not in compliance with quality and safety standards, and not suitable for the production of sterile or infused products. As a result, production has been suspended in two facilities: a National Cancer Institute laboratory engaged in cell therapy production and a National Institute of Mental Health facility producing positron emission tomography (PET) materials.
A new study has found that drinking water from private wells, particularly dug wells established during the first half of the 20th century, may have contributed to the elevated risk of bladder cancer that has been observed in Maine, New Hampshire, and Vermont for over 50 years. Other risk factors for bladder cancer, such as smoking and occupational exposures, did not explain the excess risk in this region. The study, by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, and colleagues at the Geisel School of Medicine at Dartmouth, Hanover, New Hampshire; the departments of health for Maine, New Hampshire, and Vermont; and the U.S. Geological Survey, appeared May 2, 2016, in the Journal of the National Cancer Institute.
Bladder cancer mortality rates have been elevated in northern New England for over half a century. The incidence of bladder cancer in Maine, New Hampshire, and Vermont has been about 20 percent higher than that in the United States overall. Rates are elevated among both men and women. A unique feature of this region is the high proportion of the population using private wells for their drinking water, which are not maintained by municipalities and are not subject to federal regulations. These wells may contain arsenic, generally at low to moderate levels. Previous studies have shown that consumption of water containing high concentrations of arsenic increases the risk of bladder cancer.
In a study of nearly 650 people with the eye disease age-related macular degeneration (AMD), half still had vision 20/40 or better, typically good enough to drive or to read standard print, after five years of treatment with anti-VEGF drugs that are injected into the eye. The authors of the study, funded by the National Eye Institute (NEI) at the National Institutes of Health, say those outcomes would have been unimaginable about 10 years ago, prior to the drugs’ availability.
The results were published in the journal Ophthalmology and presented May 2nd at the annual meeting of the Association for Research in Vision and Ophthalmology (ARVO) in Seattle.
Dental health insurance is the insurance that covers expenses related to treating dental problems and is available through various dental insurance companies such as Aetna, United Health Care, Primecare, Delta Dental and others. Dental health insurance is available for individuals, small businesses, and families as well. Dental health insurance plans are one way of ensuring individuals and families get regular dental check ups. There are several different types of dental health insurance plans, but there are four kinds that are most commonly purchased. Finally, these types of plans are much different than discount dental plans because they are indemnity plans, capitation programs or schedule-of-allowance programs
The first company to enable individuals to both comparison-shop and apply for dental health insurance and discount protection directly via the Internet. Medicarecard. com is a provider of free quotes and advice for buying dental health insurance and discount plans that provide group, family and individual coverage. There also are other dental health insurance key terms, such as predetermination of costs and annual benefits limitations.
A direct reimbursement dental health insurance plan reimburses participants on the amount they spend on any dental service rather than covering the type of service performed. In dental health insurance, usual, customary and reasonable (UCR) is used to determine how much of the cost of a dental service an insurance company will agree to pay.
On World Asthma Day 2016, the National Institutes of Health reaffirms its commitment to support research to improve the lives of all people with asthma. NIH-funded research has advanced our understanding of asthma as a disease as well as the impact asthma has on the lives of those affected. We have made great strides in learning how to treat and prevent asthma, and we are committed to ensuring that scientific discoveries move quickly into clinical practice to provide the best possible care for all people with asthma.
Asthma is a chronic disease that intermittently inflames and narrows the airways. People with asthma may experience wheezing, breathlessness, chest tightness and coughing when the airways narrow. Roughly 300 million people worldwide live with this condition, including approximately 24 million in the United States. In the United States, asthma is a major contributing factor to missed time from school and work, and is also a major cause of hospitalization and emergency department visits.
Through the use of powerful genomic techniques, researchers at the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) have found that the development of immune cells, called innate lymphoid cells (ILCs), gradually prepares these cells for rapid response to infection. This work, which appeared online today in Cell, sheds light on the development and function of a cell type that is increasingly recognized as having an important role in the body’s immune defense. NIAMS is part of the National Institutes of Health.
An experimental malaria vaccine protected a small number of healthy, malaria-naïve adults in the United States from infection for more than one year after immunization, according to results from a Phase 1 trial described in the May 9th issue of Nature Medicine. The vaccine, known as the PfSPZ Vaccine, was developed and produced by Sanaria Inc., of Rockville, Maryland, with support from several Small Business Innovation Research (SBIR) awards from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. NIAID researchers and collaborators at the University of Maryland School of Medicine in Baltimore, conducted the clinical evaluation of the vaccine, which involved immunization and exposing willing healthy adults to the malaria-causing parasite Plasmodium falciparum (P. falciparum) in a controlled setting.
Science Genetics Association Consortium (SSGAC) and supported in part by the National Institutes of Health, suggest that large genetics analyses may be able to help discover biological pathways as well.
The genome-wide association study (GWAS) was supported by the National Institute on Aging (NIA) and the Office of Behavioral and Social Sciences Research, both part of NIH, and appears in the May 11, 2016, issue of Nature.
Nematode worms may not be from Mars or Venus, but they do have sex-specific circuits in their brains that cause the males and females to act differently. According to new research published in Nature, scientists have determined how these sexually dimorphic (occurring in either males or females) connections arise in the worm nervous system. The research was funded by the NIH’s National Institute of Neurological Disorders and Stroke (NINDS).
“For decades, there has been little focus on the impact of sex on many areas of biomedical research,” said Coryse St. Hillaire-Clarke, Ph.D., program officer on this NINDS project. “This study helps us understand how sex can influence brain connectivity.
Because medical benefits differ significantly from policy to policy, each patient should review their orthodontic insurance coverage. However, if a patient has orthodontic insurance, Invisalign Braces should be covered to the same extent as conventional braces. Most insurance companies cover most or all of the most of Invisalign, treating it as if you got traditional braces.
The cost of the Invisalign treatment is comparable to that of traditional braces ranging from $3,000 to $5,000. The cost depends on the severity of your malocclusion and how may aligners, time, and effort, it will take to fix your teeth. However, only your dentist can determine the actual cost of treatment because it will be based on your specific needs, including how extensive your dental problems are, how long your treatment will last, etc.
Treatment with Invisalign may cost as much as 20 to 50 percent more than traditional orthodontic treatments. Geographic locations of orthodontist also effects the average Invisalign cost. You should inquire directly with your insurance company to determine whether the cost of Invisalign is fully or partially covered.
Invisalign, invisible braces, straightens your teeth without using bands, metal brackets or metal wires making Invisalign more visually appealing. Invisalign also allows you to brush and floss normally to maintain healthy gums and teeth; and there are no wires, metal or brackets to cause mouth abrasions and discomfort.
Invisalign Teen system straightens your teeth with custom made clear aligners that are comfortable and invisible. The aligners give less force per week and less pain than do fixed appliances (traditional metal braces). Invisalign is known for being much faster than traditional braces with most treatment times lasting less than a year.
How Do Invisalign Braces – Effectively Move Teeth
Like brackets and arch wires, Invisalign braces or aligners move teeth through the appropriate placement of controlled force on the teeth. The principal difference is that Invisalign braces not only control forces, but also controls the timing of the force application. Instead of pulling your teeth to their target position like traditional braces, Invisalign pushes your teeth to its location. At each stage, only certain teeth are allowed to move, and these movements are determined by the orthodontic treatment plan for that particular stage. Invisalign 3D imaging technology plans out the movement and figures out how many aligners will be needed to get the job done.
Invisalign Express for example is more affordable, because it is for minor spacing issues and needs very few aligners to get the job done. Invisalign is revolutionary because instead of the “metal bracket” traditional braces, Invisalign is invisible while still straightening your teeth.
Invisalign may not be appropriate for certain cases of misalignment or complex bit problems. If Invisalign is not appropriate, traditional orthodontics can still be used for such conditions as: Crowding and spacing fret then five millimeters. Invisalign is currently approved for adults and teenagers with completely erupted permanent teeth who can faithfully follow the directions for treatment.
How long they have to wear the aligners each day, what they can and cannot eat and drink, seeing their dentist for follow up appointments. Invisalign may also be a alternative for certain simple malocclusions (bit irregularities). Invisalign braces are great because they are hardly noticeable when you wear them, and they are removable. Clear braces can give you that beautiful smile by straightening your teeth without anyone knowing.
Your Invisalign treatment will consist of a series of clear plastic aligners that you change out approximately every two weeks. Each aligner is individually manufactured with exact calculations of your teeth. Since your Invisalign system is custom made for your teeth and your teeth only, with a plan devised by you and your dentist or orthodontist, you know you’ll end up with a smile that truly fits.
Today, Invisalign brand of orthodontic appliance, primarily because the removable aligners (less than one millimeter thick) are designed to be more esthetically pleasing than conventional wire and bracket dental braces for treating certain types of minor misaligned tooth problems.