Funded study shows reduction in death for men with intermediate-grade prostate cancer

Short-term hormone therapy given in combination with radiation therapy to men with early-stage prostate cancer increased their chances of living longer compared to treatment with radiation therapy alone, according to a clinical trial supported by the National Cancer Institute (NCI), part of the National Institutes of Health. Benefits of the combined treatment were limited mainly … Read more

Science News NIMH RAISE Project Makes Progress as Teams Refine Research Approaches

Researchers continue to make progress in the NIMH Recovery After an Initial Schizophrenia Episode (RAISE) Project, which seeks to intervene at the earliest stages of illness in order to prevent long term disability. Recent refinements to the two RAISE studies will ensure that RAISE continues efficiently, and generates results that will be relevant to consumers … Read more

Led Team Maps Route for Eliciting HIV Neutralizing Antibodies

Researchers have traced in detail how certain powerful HIV neutralizing antibodies evolve, a finding that generates vital clues to guide the design of a preventive HIV vaccine, according to a study appearing in Science Express this week. The discoveries were made by a team led by the Vaccine Research Center (VRC) at the National Institute … Read more

New model of ALS is based on human cells from autopsied tissue

By isolating cells from patients’ spinal tissue within a few days after death, researchers funded by the National Institutes of Health have developed a new model of the paralyzing disease amyotrophic lateral sclerosis (ALS). They found that during the disease, cells called astrocytes become toxic to nerve cells — a result previously found in animal … Read more

Investigators discover new mechanism that may be important for learning and memory

New findings in mice suggest that the timing when the neurotransmitter acetylcholine is released in the brain’s hippocampus may play a key role in regulating the strength of nerve cell connections, called synapses. Understanding the complex nature of neuronal signaling at synapses could lead to better understanding of learning and memory, and novel treatments for … Read more

Funded study proposes new method to predict fertility rates

Researchers supported by the National Institutes of Health have developed a new statistical technique to forecast changes in fertility rates. The new method mathematically compensates for uncertainty and is expected to allow governments to plan more reliably for the infrastructure and social services needed to accommodate large-scale population changes.

Researchers develop mouse with ‘off switch’ in key brain cell population

NIH-funded scientists have developed a strain of mice with a built-in off switch that can selectively shut down the animals’ serotonin-producing cells, which make up a brain network controlling breathing, temperature regulation, and mood. The switch controls only the serotonin-producing cells, and does not affect any other cells in the animal’s brains or bodies.

Research convenes national summit on The Science of Compassion: Future Directions in End-of-Life and Palliative Care

The National Institute of Nursing Research (NINR), a component of the National Institutes of Health, and its partners will host The Science of Compassion: Future Directions in End-of-Life and Palliative Care. This trans-NIH summit aims to examine the current status of end-of-life and palliative care research and practice; propose strategies to address current barriers to … Read more

Researchers identify gene variant in Proteus syndrome

A team of researchers has identified the genetic mutation that causes Proteus syndrome, a rare disorder in which tissue and bone grows massively out of proportion. The discovery, which has implications for potential drug therapies and even cancer, appears in the July 27, 2011, early online edition of the New England Journal of Medicine. The … Read more

Standard aplastic anemia therapy improves patient outcomes better than newer version

A comparison clinical study of two aplastic anemia treatments found that ATGAM, currently the only licensed aplastic anemia drug in the United States, improved blood cell counts and survival significantly more than Thymoglobulin, a similar but reportedly more potent treatment. The research was carried out by the National Heart, Lung and Blood Institute (NHLBI), part … Read more