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1. Systemic lupus erythematosus: From mouse models to human disease and treatment On Sept. 2-3, 2010, the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Cancer Institute (NCI), the National Institute of Allergy and Infectious Diseases (NIAID), and the NIH Office of Research on Women’s Health (ORWH) will convene a two-day conference on Systemic Lupus Erythematosus: From Mouse Models to Human Disease and […]...
2. Jake vs. Mouse I have two cats and a mouse as pets, but I don’t want the mouse. I have always said that the mouse that tried to live in our apartment would be the least intelligent animal ever but it turns out he’s probably one of the smartest–right up there with Flipper, Lassie and that horse that could do arithmetic simply because he […]...
3. Medicare Mouse study shows effect of blood pressure drug on Alzheimer’s disease A drug used decades ago to treat high blood pressure has been shown to improve learning and memory in mouse models of Alzheimer’s disease, according to a new study by researchers at the National Institute on Aging (NIA), part of the National Institutes of Health. The study found that the drug, diazoxide, acted on nerve […]...
4. Medicare: Researchers produce detailed map of gene activity in mouse brain A new atlas of gene expression in the mouse brain provides insight into how genes work in the outer part of the brain called the cerebral cortex. In humans, the cerebral cortex is the largest part of the brain, and the region responsible for memory, sensory perception and language....
5. NIH-funded study shows early brain effects of HIV in mouse model A new mouse model closely resembles how the human body reacts to early HIV infection and is shedding light on nerve cell damage related to the disease, according to researchers funded by the National Institutes of Health....
6. Genetic mutation linked to inherited forms of ALS, dementia National Institutes of Health scientists and worldwide teams of researchers have identified the most common genetic cause known to date for two neurological diseases, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The discovery offers clues to underlying mechanisms of these diseases, and may eventually contribute to the design and testing of possible therapies....
7. MedicarCard.com, NIH, Human Microbiome Project, Researchers Publish First Genomic, Collection of Human Microbes The Human Microbiome Project (HMP) today published an analysis of 178 genomes from microbes that live in or on the human body. The researchers discovered novel genes and proteins that serve functions in human health and disease, adding a new level of understanding to what is known about the complexity and diversity of these organisms....
8. Origins of XMRV deciphered, undermining claims for a role in human disease Delineation of the origin of the retrovirus known as XMRV from the genomes of laboratory mice indicates that the virus is unlikely to be responsible for either prostate cancer or chronic fatigue syndrome in humans, as has been widely published. The virus arose because of genetic recombination of two mouse viruses. Subsequent infection of lab […]...
9. NIH-supported mouse studies suggest treatment target for alcohol problems A molecular pathway within the brain’s reward circuitry appears to contribute to alcohol abuse, according to laboratory mouse research supported by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health (NIH). The findings, published online today in Proceedings of the National Academy of Sciences, also provide evidence that […]...
10. Study Suggests Metabolic Network Finds Disease Links Study Suggests Metabolic Network Finds Disease Links...
11. USU study maps hotspots of genetic rearrangement Researchers have zoomed in on mouse chromosomes to map hotspots of genetic recombination — sites where DNA breaks and reforms to shuffle genes. The findings of the scientists at the National Institutes of Health and Uniformed Services University of Health Sciences (USU) have the potential to improve the detection of genes linked to disease and […]...
12. Medicare Card, Scientists Identify Markers, Human Breast Cancer Cells, Linked to Development of an Aggressive, But Less Common Form of Breast Cancer Scientists have identified a group of surface markers on cells linked to an aggressive type of breast cancer called estrogen receptor-negative cancer. In this preliminary study, estrogen-negative breast cancer developed when three markers, CD44+, CD49fhi, and CD133hi were present simultaneously on the surface of human cells taken from breast cancer patients and transplanted into a […]...
13. Researchers develop mouse with ‘off switch’ in key brain cell population NIH-funded scientists have developed a strain of mice with a built-in off switch that can selectively shut down the animals’ serotonin-producing cells, which make up a brain network controlling breathing, temperature regulation, and mood. The switch controls only the serotonin-producing cells, and does not affect any other cells in the animal’s brains or bodies....
14. MedicareCard.com – Scientists Find Genes That Influence Brain Wave Patterns Scientists have identified new genes and pathways that influence an individual’s typical pattern of brain electrical activity, a trait that may serve as a useful surrogate marker for more genetically complex traits and diseases. One of the genes, for example, was found to be associated with alcoholism....
15. Researchers identify genetic cause of new vascular disease Clinical researchers at the National Institutes of Health’s Undiagnosed Diseases Program (UDP) have identified the genetic cause of a rare and debilitating vascular disorder not previously explained in the medical literature. The adult-onset condition is associated with progressive and painful arterial calcification affecting the lower extremities, yet spares patients’ coronary arteries. The new disease finding […]...