NIH-sponsored research yields promising malaria drug candidate

A chemical that rid mice of malaria-causing parasites after a single oral dose may eventually become a new malaria drug if further tests in animals and people uphold the promise of early findings. The compound, NITD609, was developed by an international team of researchers including Elizabeth A. Winzeler, Ph.D., a grantee of the National Institute … Read more

Third generation map of human genetic variation published

An international consortium today published a third-generation map of human genetic variation, called the HapMap, which includes data from an additional seven global populations, increasing the total number to 11 populations. The improved resolution will help researchers interpret current genome studies aimed at finding common and rarer genetic variants associated with complex diseases. Find good … Read more

Lower blood pressure goal benefits African-Americans with chronic kidney disease, protein in the urine

On average, a lower blood pressure goal was no better than the standard blood pressure goal at slowing progression of kidney disease among African-Americans who had chronic kidney disease resulting from high blood pressure, according to results of the African-American Study of Kidney Disease and Hypertension (AASK), the largest and longest study of chronic kidney … Read more

New TB Diagnostic Proves Effective, Expedient, Study Finds

A molecular test designed to easily diagnose tuberculosis (TB) and detect a drug-resistant form of the bacterium that causes TB can provide much more specific, sensitive and rapid results than currently available TB diagnostics, according to a new study in the New England Journal of Medicine. In a test involving 1,730 patients with suspected drug-sensitive … Read more

Effort to define markers of human immune responses to infection and vaccination

A new nationwide research initiative has been launched to define changes in the human immune system, using human and not animal studies, in response to infection or to vaccination. Six U. S.-based Human Immune Phenotyping Centers will receive a total of $100 million over five years to conduct this research.

Study indicates stress may delay women getting pregnant

A study by researchers at the National Institutes of Health and the University of Oxford supports the widespread belief that stress may reduce a woman’s chance of becoming pregnant. The study is the first of its kind to document, among women without a history of fertility problems, an association between high levels of a substance … Read more

Medicare Card | SeniorHealth site offers information about older adults and alcohol use

Having a drink now and then as you get older is not usually thought to be harmful, but alcohol can be a problem for older adults, especially if they take certain medications, have health problems or don’t control their drinking. Alcohol Use and Older Adults, http://nihseniorhealth.gov/alcoholuse/toc.html, the newest topic on NIHSeniorHealth, provides helpful information about … Read more

NIDA, Federal Partners, Launch National Drug Facts Week

Expanding on the success of its online Drug Facts Chat Day, the National Institute on Drug Abuse (NIDA) today announced it is launching National Drug Facts Week, a new national awareness week designed to bring together teens and scientific experts to discuss the facts about drug abuse. NIDA is a component of the National Institutes … Read more

Discovered gene causes Kabuki syndrome

Using a new, rapid and less expensive DNA sequencing strategy, scientists have discovered genetic alterations that account for most cases of Kabuki syndrome, a rare disorder that causes multiple birth defects and mental retardation. Instead of sequencing the entire human genome, the new approach sequences just the exome, the 1-2 percent of the human genome … Read more

New breast cancer committee to establish federal research agenda

A newly formed advisory committee will develop and coordinate a strategic federal research agenda on environmental and genetic factors related to breast cancer. The 19-member Interagency Breast Cancer and Environmental Research Coordinating Committee (IBCERCC) was established by the National Institute of Environmental Health Sciences (NIEHS), in collaboration with the National Cancer Institute (NCI), to review … Read more

Medicare Card News, Symptoms of Bipolar Disorder May Go Undiagnosed in Some Adults with Major Depression

Nearly 40 percent of people with major depression may also have subthreshold hypomania, a form of mania that does not fully meet current diagnostic criteria for bipolar disorder, according to a new NIMH-funded study. The study was published online ahead of print August 15, 2010, in the American Journal of Psychiatry.