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On August 25, the National Park Service turned 100. Make plans to visit one of the more than 400 parks available this year. Find your park and get on the road this year.  Here are a few suggested parks you may want to visit.

1-Cumberland Gap National Historical Park-Kentucky, Tennessee, Virginia
2-San Juan National Historic Site- Puerto Rico
3-Shenandoah National Park- Virginia
4-Death Valley National Park- California, Nevada
5-Yosemite National Park- California
6-Grand Canyon National Park- Arizona
7-Fort Washington National Park- Maryland
8-Rosie the Riveter WWII Home Front National Historical Park- California
9-C&O Canal National Historical Park- District of Columbia, Virginia, Maryland
10-Olympic National Park- Washington

 

Scientists using a technology called cryo-EM (cryo-electron microscopy) have broken through a technological barrier in visualizing proteins with an approach that may have an impact on drug discovery and development. They were able to capture images of glutamate dehydrogenase, an enzyme found in cells, at a resolution of 1.8 angstroms, a level of detail at which the structure of the central parts of the enzyme could be visualized in atomic detail. The scientists from the National Cancer Institute (NCI), part of the National Institutes of Health, and their colleagues also reported achieving another major milestone, by showing that the shapes of cancer target proteins too small to be considered within the reach of current cryo-EM capabilities can now be determined at high resolution.

As part of President Obama’s Precision Medicine Initiative (PMI), the National Institutes of Health will award $142 million over five years to the Mayo Clinic, Rochester, Minnesota, to establish the world’s largest research-cohort biobank for the PMI Cohort Program, a longitudinal research study which aims to enroll 1 million or more U.S. participants to advance precision medicine. The award will support the collection, storage and distribution for research use of biological samples known as biospecimens. Laboratory analyses of the biospecimens, including chemical and genetic tests, will be a key component of the core PMI Cohort Program data set. These data, combined with other information provided by volunteers such as lifestyle and health questionnaires, medication history, electronic health records, physical exams, and environmental exposures and real time physiology tracked through mobile health technologies, will help researchers study individual differences in health and disease.

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