Patients who have inherited a specific common genetic variant develop bladder cancer tumors that strongly express a protein known as prostate stem cell antigen (PSCA), which is also expressed in many pancreatic and prostate tumors, according to research at the National Institutes of Health.

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  1. Medicare Future? Pathways that Can Repair Brca1 Cancer Gene Mutation Clarified in Mice In a new study in mice, scientists have compensated for mutations in the Brca1 gene that can lead to cancer by deleting a second gene, which then lessens the probability of cancer. Mice Brca1-associated mammary tumors have significant similarities to human BRCA1- associated (BReast CAncer 1, early onset) breast cancer in regard to tumor aggressiveness, high incidence, mutations and genetic instability. The study, led by scientists at National Cancer Institute (NCI), part of the National Institutes of Health, and their colleagues, appeared online April 1, 2010 and in print April 16, 2010, in the journal Cell....
  2. Medicare, Medicare Card, Study Finds Two Sling Surgeries, Equally Effective for Bladder Control in Women Two common operations for stress urinary incontinence (SUI) help women achieve similar levels of dryness, according to a team of urologists and urogynecologists who compared the treatments in a large U.S. trial supported by the National Institutes of Health. The study is being released online May 17, 2010, by the New England Journal of Medicine […]...
  3. Medicare, Gene variations linked to lung cancer susceptibility in Asian women An international group of scientists has identified three genetic regions that predispose Asian women who have never smoked to lung cancer. The finding provides further evidence that risk of lung cancer among never-smokers, especially Asian women, may be associated with certain unique inherited genetic characteristics that distinguishes it from lung cancer in smokers....
  4. Researchers extend use of gene therapy to treat a soft tissue tumor Researchers extend use of gene therapy to treat a soft tissue tumor...
  5. Panel endorses active monitoring and delay of treatment for low-risk prostate cancer An independent panel convened this week by the National Institutes of Health has concluded that many men with localized, low-risk prostate cancer should be closely monitored, permitting treatment to be delayed until warranted by disease progression....
  6. Study identifies gene that suppresses cell’s immune activation A new study of prostate tumors has shown that a gene, FOXO3, suppresses activation of cells related to immunity and thus leads to a reduced immune response against a growing cancer. One of the main problems in treating cancer by vaccine or immunotherapy is that tumors often evade the body’s immune response — and one […]...
  7. Medicare, NIH-led study identifies genetic variant that can lead to severe impulsivity A multinational research team led by scientists at the National Institutes of Health has found that a genetic variant of a brain receptor molecule may contribute to violently impulsive behavior when people who carry it are under the influence of alcohol. A report of the findings, which include human genetic analyses and gene knockout studies […]...
  8. Medicare, Medicare Card, Receptor Variant Influences, Dopamine Response to Alcohol A genetic variant of a receptor in the brain’s reward circuitry plays an important role in determining whether the neurotransmitter dopamine is released in the brain following alcohol intake, according to a study led by researchers at the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health. Dopamine is […]...
  9. Arsenic turns stem cells cancerous, spurring tumor growth Researchers at the National Institutes of Health have discovered how exposure to arsenic can turn normal stem cells into cancer stem cells and spur tumor growth. Inorganic arsenic, which affects the drinking water of millions of people worldwide, has been previously shown to be a human carcinogen. A growing body of evidence suggests that cancer […]...
  10. Medicare, NIH scientists identify possible gene target for treating a form of lymphoma Researchers have identified a mutation in a gene that could lead to targeted therapies for certain lymphoma patients whose cure rates are currently poor. Mutation of the MYD88 gene was found to be one of the most frequent genetic abnormalities in a form of cancer known as diffuse large B cell lymphoma. MYD88 encodes a […]...
  11. Scientists find approach to enhance and prolong immune attack against tumor cells Investigators have identified a new class of human immune cells that behave like stem cells. These cells, a subtype of T lymphocytes, which comprise a small fraction of white blood cells, may prove more effective than any previously reported type of T cell for treating tumors. The study, by scientists at the National Cancer Institute […]...
  12. Medicare Card, NHGRI to develop revolutionary technologies for exploring genome function The National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, has awarded 10 grants, totaling $10.5 million, to develop revolutionary technologies that will help researchers identify millions of genomic elements that play a role in determining what genes are expressed and at what levels in different cells. These multi-year grants are […]...
  13. Medicare, Study of MicroRNA, Helps NIH Scientists, Unlock Secrets of Immune Cells With the rapid and continuous advances in biotechnology, scientists are better able to see inside the nucleus of a cell to unlock the secrets of its genetic material. However, what happens outside of the nucleus has, in many ways, remained a mystery. Now, researchers with the National Institutes of Health are closer to understanding how […]...
  14. Medicare Card: Gene Linked to Alzheimer’s Disease Plays Key Role in Cell Survival Scientists have discovered that a gene linked to Alzheimer’s disease may play a beneficial role in cell survival by enabling neurons to clear away toxic proteins. A study funded by the National Institute on Aging (NIA), part of the National Institutes of Health, shows the presenilin 1 (PS1) gene is essential to the function of […]...
  15. Funded study shows reduction in death for men with intermediate-grade prostate cancer Short-term hormone therapy given in combination with radiation therapy to men with early-stage prostate cancer increased their chances of living longer compared to treatment with radiation therapy alone, according to a clinical trial supported by the National Cancer Institute (NCI), part of the National Institutes of Health. Benefits of the combined treatment were limited mainly […]...