Researchers have conducted studies on the safety of the artificial sweeteners (sugar substitutes) saccharin (Sweet ‘N Low®, Sweet Twin®, NectaSweet®); cyclamate; aspartame (Equal®, NutraSweet®); acesulfame potassium (Sunett®, Sweet One®); sucralose (Splenda®); and neotame and found no evidence that they cause cancer in humans. All of these artificial sweeteners except for cyclamate have been approved by the Food and Drug Administration for sale in the United States.

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