People who scored high on a test that measures impulsive and antisocial traits had exaggerated brain responses to certain “rewards,” like winning money or taking stimulant drugs. The new study provides evidence that a dysfunctional brain reward system may underlie vulnerability to a personality disorder known as psychopathy.

Brain image with 2 small red and yellow patches.
Impulsive and antisocial personality traits correlate with amphetamine-induced dopamine release (red and yellow) in the brain. Image by Buckholtz et al.

Psychopathy is characterized by a combination of superficial charm, manipulative and antisocial behavior, impulsivity, blunted empathy and shallow emotional experiences. Psychopathy is a reliable predictor of criminal behavior and repeat offenders. Research also suggests that psychopathic people are at increased risk for substance abuse.

Many studies of psychopathy have focused on the emotional and interpersonal aspects of the disorder, like lack of fear and empathy. But Joshua W. Buckholtz and his colleagues at Vanderbilt University decided to take a closer look at a different facet of psychopathy that’s linked to socially deviant behavior, impulsivity, aggression and …

For more information see http://www.nih.gov/researchmatters/march2010/03292010brain.htm

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